DNA polymerase θ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability
نویسندگان
چکیده
Fanny Lemée, Valérie Bergoglio, Anne Fernandez-Vidal, Alice Machado-Silva, Marie-Jeanne Pillaire, Anne Bieth, Catherine Gentil, Lee Baker, Anne-Laure Martin, Claire Leduc, Elena Lam, Eddy Magdeleine, Thomas Filleron, Naïma Oumouhou, Bernd Kaina, Mineaki Seki, Fanny Grimal, Magali Lacroix-Triki, Alastair Thompson, Henri Roché, Jean-Christophe Bourdon, Richard D. Wood, Jean-Sébastien Hoffmann, and Christophe Cazaux
منابع مشابه
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
"Replicative stress" is one of the main factors underlying neoplasia from its early stages. Genes involved in DNA synthesis may therefore represent an underexplored source of potential prognostic markers for cancer. To this aim, we generated gene expression profiles from two independent cohorts (France, n=206; United Kingdom, n=117) of patients with previously untreated primary breast cancers. ...
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